Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.

@article{Li2011Orai1AC,
  title={Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation.},
  author={Jing Li and Richard M Cubbon and Lesley A. Wilson and Mohamed S. Amer and Lynn McKeown and Bing Hou and Yasser Majeed and Sarka Tumova and Victoria A. L. Seymour and Hilary Taylor and Martin Stacey and David J O'regan and Richard Foster and Karen E Porter and Mark T Kearney and David J Beech},
  journal={Circulation research},
  year={2011},
  volume={108 10},
  pages={
          1190-8
        }
}
RATIONALE Orai1 and the associated calcium release-activated calcium (CRAC) channel were discovered in the immune system. Existence also in endothelial cells has been suggested, but the relevance to endothelial biology is mostly unknown. OBJECTIVE The aim of this study was to investigate the relevance of Orai1 and CRAC channels to vascular endothelial growth factor (VEGF) and endothelial tube formation. METHODS AND RESULTS In human umbilical vein endothelial cells, Orai1 disruption by short… CONTINUE READING
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