Optogenetic stimulation of a hippocampal engram activates fear memory recall

@inproceedings{Liu2012OptogeneticSO,
  title={Optogenetic stimulation of a hippocampal engram activates fear memory recall},
  author={Xu Wen Liu and Steve Ramirez and Petti T. Pang and Corey B. Puryear and Arvind Govindarajan and Karl Deisseroth and Susumu Tonegawa},
  booktitle={Nature},
  year={2012}
}
A specific memory is thought to be encoded by a sparse population of neurons. These neurons can be tagged during learning for subsequent identification and manipulation. Moreover, their ablation or inactivation results in reduced memory expression, suggesting their necessity in mnemonic processes. However, the question of sufficiency remains: it is unclear whether it is possible to elicit the behavioural output of a specific memory by directly activating a population of neurons that was active… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 379 extracted citations

The conjunctive trace.

View 4 Excerpts
Highly Influenced

Fear Memory.

View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Molecular and cellular approaches to memory allocation in neural circuits

AJ Silva
2009

Similar Papers

Loading similar papers…