Optogenetic inhibition of chemically induced hypersynchronized bursting in mice

@article{Berglind2014OptogeneticIO,
  title={Optogenetic inhibition of chemically induced hypersynchronized bursting in mice},
  author={Fredrik Berglind and Marco Ledri and Andreas Toft S{\o}rensen and Litsa Nikitidou and Merab Kokaia},
  journal={Neurobiology of Disease},
  year={2014},
  volume={65},
  pages={133-141}
}
Synchronized activity is common during various physiological operations but can culminate in seizures and consequently in epilepsy in pathological hyperexcitable conditions in the brain. Many types of seizures are not possible to control and impose significant disability for patients with epilepsy. Such intractable epilepsy cases are often associated with degeneration of inhibitory interneurons in the cortical areas resulting in impaired inhibitory drive onto the principal neurons. Recently… CONTINUE READING
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