Optogenetic excitation of preBötzinger complex neurons potently drives inspiratory activity in vivo.

@article{Alsahafi2015OptogeneticEO,
  title={Optogenetic excitation of preB{\"o}tzinger complex neurons potently drives inspiratory activity in vivo.},
  author={Zaki Alsahafi and Clayton T. Dickson and Silvia Pagliardini},
  journal={The Journal of physiology},
  year={2015},
  volume={593 16},
  pages={3673-92}
}
KEY POINTS This study investigates the effects on ventilation of an excitatory stimulus delivered in a spatially and temporally precise manner to the inspiratory oscillator, the preBötzinger complex (preBötC). We used an adeno-associated virus expressing channelrhodopsin driven by the synapsin promoter to target the region of the preBötC. Unilateral optogenetic stimulation of preBötC increased respiratory rate, minute ventilation and increased inspiratory modulated genioglossus muscle activity… CONTINUE READING
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Biostatistical Analysis

  • JH 508–520. Zar
  • 1996
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