Optogenetic drive of neocortical pyramidal neurons generates fMRI signals that are correlated with spiking activity

@article{Kahn2013OptogeneticDO,
  title={Optogenetic drive of neocortical pyramidal neurons generates fMRI signals that are correlated with spiking activity},
  author={Itamar Kahn and Ulf Knoblich and Mohati Desai and Joe Bernstein and Christopher I. Moore},
  journal={Brain Research},
  year={2013},
  volume={1511},
  pages={33-45}
}
Local fluctuations in the blood oxygenation level-dependent (BOLD) signal serve as the basis of functional magnetic resonance imaging (fMRI). Understanding the correlation between distinct aspects of neural activity and the BOLD response is fundamental to the interpretation of this widely used mapping signal. Analysis of this question requires the ability to precisely manipulate the activity of defined neurons. To achieve such control, we combined optogenetic drive of neocortical neurons with… CONTINUE READING

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