Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

@article{Bruegmann2016OptogeneticDT,
  title={Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.},
  author={Tobias Bruegmann and Patrick M. Boyle and Christoph C. Vogt and Thomas V. Karathanos and Hermenegild Arevalo and Bernd K Fleischmann and Natalia A. Trayanova and Philipp Sasse},
  journal={The Journal of clinical investigation},
  year={2016},
  volume={126 10},
  pages={
          3894-3904
        }
}
Ventricular arrhythmias are among the most severe complications of heart disease and can result in sudden cardiac death. Patients at risk currently receive implantable defibrillators that deliver electrical shocks to terminate arrhythmias on demand. However, strong electrical shocks can damage the heart and cause severe pain. Therefore, we have tested optogenetic defibrillation using expression of the light-sensitive channel channelrhodopsin-2 (ChR2) in cardiac tissue. Epicardial illumination… CONTINUE READING
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