Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks

@article{Soper2016OptogeneticAO,
  title={Optogenetic activation of superior colliculus neurons suppresses seizures originating in diverse brain networks},
  author={Colin J. Soper and Evan Wicker and Catherine V Kulick and Prosper N’Gouemo and Patrick A Forcelli},
  journal={Neurobiology of Disease},
  year={2016},
  volume={87},
  pages={102-115}
}
Because sites of seizure origin may be unknown or multifocal, identifying targets from which activation can suppress seizures originating in diverse networks is essential. We evaluated the ability of optogenetic activation of the deep/intermediate layers of the superior colliculus (DLSC) to fill this role. Optogenetic activation of DLSC suppressed behavioral and electrographic seizures in the pentylenetetrazole (forebrain+brainstem seizures) and Area Tempestas (forebrain/complex partial… CONTINUE READING

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