Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

@article{Li2015OptogeneticAO,
  title={Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory},
  author={Ping Li and Daniel Rial and Paula M Canas and J Yoo and Wei Li and Xujiao Zhou and Yuxi Wang and Guus van Westen and M-P Payen and Elisabete de Oliveira Augusto and N{\'e}lio Gonçalves and Adriana da Rocha Tom{\'e} and Zheyi Li and Zhihao Wu and Xianhua Hou and Yufu Zhou and Ad PIJzerman and Edward S. Boyden and Rodrigo A Cunha and Jingrong Qu and J-F Chen},
  journal={Molecular Psychiatry},
  year={2015},
  volume={20},
  pages={1339-1349}
}
Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer’s disease through the antagonism of adenosine A2A receptors (A2ARs). To test if A2AR activation in the hippocampus is actually sufficient to impair memory function and to begin elucidating the intracellular pathways operated by A2AR, we have developed a chimeric rhodopsin-A2AR protein (optoA2AR), which retains the extracellular and transmembrane domains of rhodopsin… CONTINUE READING
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