Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.

  title={Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity.},
  author={Benjamin M. Gaub and Michael H Berry and Amy E Holt and Ehud Y Isacoff and John G Flannery},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={23 10},
Retinal disease is one of the most active areas of gene therapy, with clinical trials ongoing in the United States for five diseases. There are currently no treatments for patients with late-stage disease in which photoreceptors have been lost. Optogenetic gene therapies are in development, but, to date, have suffered from the low light sensitivity of microbial opsins, such as channelrhodopsin and halorhodopsin, and azobenzene-based photoswitches. Several groups have shown that photoreceptive G… CONTINUE READING
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