Optogenetic Stimulation of Frontal D1 Neurons Compensates for Impaired Temporal Control of Action in Dopamine-Depleted Mice.

Abstract

Disrupted mesocortical dopamine contributes to cognitive symptoms of Parkinson's disease (PD). Past work has implicated medial frontal neurons expressing D1 dopamine receptors (D1DRs) in temporal processing. Here, we investigated whether these neurons can compensate for behavioral deficits resulting from midbrain dopamine dysfunction. We report three main… (More)
DOI: 10.1016/j.cub.2016.11.029

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@article{Kim2017OptogeneticSO, title={Optogenetic Stimulation of Frontal D1 Neurons Compensates for Impaired Temporal Control of Action in Dopamine-Depleted Mice.}, author={Young-Cho Kim and Sang-Woo Han and Stephanie L. Alberico and Rafael Naime Ruggiero and Benjamin J De Corte and Kuan-Hua Chen and Nandakumar S. Narayanan}, journal={Current biology : CB}, year={2017}, volume={27 1}, pages={39-47} }