Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123

@inproceedings{Daou2016OptogeneticSO,
  title={Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain123},
  author={Ihab Daou and H{\'e}l{\`e}ne Beaudry and Ariel R. Ase and Jeffrey S. Wieskopf and Alfredo Ribeiro-da-Silva and Jeffrey S. Mogil and Philippe S{\'e}gu{\'e}la},
  booktitle={eNeuro},
  year={2016}
}
We report a novel transgenic mouse model in which the terminals of peripheral nociceptors can be silenced optogenetically with high spatiotemporal precision, leading to the alleviation of inflammatory and neuropathic pain. Inhibitory archaerhodopsin-3 (Arch) proton pumps were delivered to Nav1.8(+) primary afferents using the Nav1.8-Cre driver line. Arch… CONTINUE READING