Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement

@inproceedings{Kim2012OptogeneticMO,
  title={Optogenetic Mimicry of the Transient Activation of Dopamine Neurons by Natural Reward Is Sufficient for Operant Reinforcement},
  author={Kyung Man Kim and Michael V Baratta and Aimei Yang and Doheon Lee and Edward S. Boyden and Christopher D. Fiorillo},
  booktitle={PloS one},
  year={2012}
}
Activation of dopamine receptors in forebrain regions, for minutes or longer, is known to be sufficient for positive reinforcement of stimuli and actions. However, the firing rate of dopamine neurons is increased for only about 200 milliseconds following natural reward events that are better than expected, a response which has been described as a "reward prediction error" (RPE). Although RPE drives reinforcement learning (RL) in computational models, it has not been possible to directly test… CONTINUE READING
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