Optogenetic Manipulation of Cerebellar Purkinje Cell Activity In Vivo

  title={Optogenetic Manipulation of Cerebellar Purkinje Cell Activity In Vivo},
  author={Tadashi Tsubota and Yohei Ohashi and Keita Tamura and Ayana Sato and Yasushi Miyashita},
  booktitle={PloS one},
Purkinje cells (PCs) are the sole output neurons of the cerebellar cortex. Although their anatomical connections and physiological response properties have been extensively studied, the causal role of their activity in behavioral, cognitive and autonomic functions is still unclear because PC activity cannot be selectively controlled. Here we developed a novel technique using optogenetics for selective and rapidly reversible manipulation of PC activity in vivo. We injected into rat cerebellar… CONTINUE READING


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