Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis.

  title={Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis.},
  author={Zahra Shiri and Maxime L{\'e}vesque and Guillaume Etter and Fr{\'e}d{\'e}ric Manseau and Sylvain Williams and Massimo Avoli},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={37 11},
Despite many advances made in understanding the pathophysiology of epileptic disorders, seizures remain poorly controlled in approximately one-third of patients with mesial temporal lobe epilepsy. Here, we established the efficacy of cell type-specific low-frequency stimulation (LFS) in controlling ictogenesis in the mouse entorhinal cortex (EC) in an in vitro brain slice preparation. Specifically, we used 1 Hz optogenetic stimulation of calcium/calmodulin-dependent protein kinase II-positive… CONTINUE READING
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