Optogenetic Inhibitor of the Transcription Factor CREB.

Abstract

Current approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors. Optogenetic control of dominant negative versions of endogenous transcription factors provides a mechanism for mimicking the natural regulation of gene… (More)
DOI: 10.1016/j.chembiol.2015.09.018

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