Optogenetic Control of Synaptic Composition and Function

  title={Optogenetic Control of Synaptic Composition and Function},
  author={Brooke L. Sinnen and Aaron B Bowen and Jeffrey S. Forte and Brian G. Hiester and Kevin C. Crosby and Emily S. Gibson and Mark L. Dell’Acqua and Matthew J Kennedy},
The molecular composition of the postsynaptic membrane is sculpted by synaptic activity. During synaptic plasticity at excitatory synapses, numerous structural, signaling, and receptor molecules concentrate at the postsynaptic density (PSD) to regulate synaptic strength. We developed an approach that uses light to tune the abundance of specific molecules in the PSD. We used this approach to investigate the relationship between the number of AMPA-type glutamate receptors in the PSD and synaptic… CONTINUE READING