Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy

@inproceedings{Ryan2018OptineurinAC,
  title={Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy},
  author={Thomas A. Ryan and David A Tumbarello},
  booktitle={Front. Immunol.},
  year={2018}
}
Optineurin is a multifunctional adaptor protein intimately involved in various vesicular trafficking pathways. Through interactions with an array of proteins, such as myosin VI, huntingtin, Rab8, and Tank-binding kinase 1, as well as via its oligomerisation, optineurin has the ability to act as an adaptor, scaffold, or signal regulator to coordinate many cellular processes associated with the trafficking of membrane-delivered cargo. Due to its diverse interactions and its distinct functions… CONTINUE READING