Optimum treatment allocation rules under a variance heterogeneity model.

@article{Wong2008OptimumTA,
  title={Optimum treatment allocation rules under a variance heterogeneity model.},
  author={Weng Kee Wong and Wei Zhu},
  journal={Statistics in medicine},
  year={2008},
  volume={27 22},
  pages={
          4581-95
        }
}
We provide optimal treatment allocation schemes when the outcome variance varies across the treatment groups and our objectives are to estimate treatment effects with equal or unequal interest. Unlike other optimal designs, such as A-optimal designs, the proposed designs can be found without an iterative scheme. We evaluate robustness properties of the optimal designs to mis-specification in the expected variance from each group and identify situations when popular allocation schemes have poor… CONTINUE READING
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