Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages.

Abstract

We examined the phagocytic activities of alveolar macrophages (NR8383 cells) toward poly(lactic-co-glycolic) acid (PLGA) microspheres (MS) loaded with the anti-tuberculosis agent rifampicin (RFP), the sizes of which were between 1 microm and 10 microm. We found that 1) the phagocytosis was dependent greatly on the particle size and the number of particles… (More)

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Cite this paper

@article{Hirota2007OptimumCF, title={Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages.}, author={Keiji Hirota and Taizo Hasegawa and Hideyuki Hinata and Fuminori Ito and Hiroyuki Inagawa and Chie Kochi and Gen-ichiro Soma and Kimiko Makino and Hiroshi Terada}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2007}, volume={119 1}, pages={69-76} }