Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice.

@article{Igarashi2007OptimumCF,
  title={Optimum conditions for detecting hepatic micronuclei caused by numerical chromosome aberration inducers in mice.},
  author={Miyuki Igarashi and Mayumi Setoguchi and Sanae Takada and Satoru Itoh and Kazuhisa Furuhama},
  journal={Mutation research},
  year={2007},
  volume={632 1-2},
  pages={89-98}
}
To ascertain an optimum condition for detecting micronuclei in the liver caused by numerical aberration inducers, either carbendazim (125-1000mg/kg, p.o.), colchicine (0.375-1.5mg/kg, i.v.), cytochalasin B (2.5-20mg/kg, i.v.), diazepam (3.13-25mg/kg, i.v.), noscapine (7.8-62.5mg/kg, i.v.), paclitaxel (1-100mg/kg, i.v.) or trichlorfon (18.75-150mg/kg, i.v.) was administered once to male Slc:ddY mice 1 day before or after partial hepatectomy (PH, Day 1). Five days after PH (on Day 6), hepatic… CONTINUE READING