Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis.

Abstract

Small-sized (less than 150 nm) long-circulating liposomes (LCL) may be useful as drug-targeting vehicles for anti-inflammatory agents in arthritis, since they selectively home at inflamed joints after i.v. administration. Previously it was shown in experimental arthritis that encapsulation of glucocorticoids (GC) as water-soluble phosphate esters in PEG… (More)
DOI: 10.1016/j.ijpharm.2011.03.025

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@article{Hoven2011OptimizingTT, title={Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis.}, author={Jolanda M van den Hoven and Wouter Hofkens and Marca H M Wauben and Josee P.A. Wagenaar-Hilbers and Jos H. Beijnen and Bastiaan Nuijen and Josbert M. Metselaar and Gert Storm}, journal={International journal of pharmaceutics}, year={2011}, volume={416 2}, pages={471-7} }