Optimizing the dosing regimen of linezolid in critically ill septic patients undergoing continuous hemodiafiltration using a pharmacokinetic/pharmacodynamic analysis and monte carlo simulation

@inproceedings{Gonzlez2015OptimizingTD,
  title={Optimizing the dosing regimen of linezolid in critically ill septic patients undergoing continuous hemodiafiltration using a pharmacokinetic/pharmacodynamic analysis and monte carlo simulation},
  author={H Barrasa Gonz{\'a}lez and A Mart{\'i}n L{\'o}pez and A Isla Ruiz and Alicia Rodr{\'i}guez Gasc{\'o}n and A Soraluce Ola{\~n}eta and E As{\'i}n Prieto and A Canut Blasco and J{\'A} S{\'a}nchez Izquierdo and B Fern{\'a}ndez Miret and A Vallejo De la Cueva and FJ Maynar Moliner},
  booktitle={Intensive care medicine experimental},
  year={2015}
}
Methods Study developed in three tertiary hospitals in patients with severe sepsis, HDF and treatment with LZ (600mg q12h). 8 each patient blood (prefilter and postfilter) and ultrafiltrate samples were taken. Concentrations of linezolid were determined by HPLC-UV. PK analysis and MCS were performed using Phoenix WinNonlin Version 6.3 (Pharsight) and Oracle… CONTINUE READING