Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting.

@article{Mandalakas2015OptimizingTD,
  title={Optimizing the detection of recent tuberculosis infection in children in a high tuberculosis-HIV burden setting.},
  author={Anna Maria Mandalakas and H. Lester Kirchner and Gerhard Walzl and Robert Gie and Hendrik Simon Schaaf and M F Cotton and Harleen M. S. Grewal and Anneke Catharina Hesseling},
  journal={American journal of respiratory and critical care medicine},
  year={2015},
  volume={191 7},
  pages={820-30}
}
RATIONALE Children who are young, malnourished, and infected with HIV have significant risk of tuberculosis (TB) morbidity and mortality following TB infection. Treatment of TB infection is hindered by poor detection and limited pediatric data. OBJECTIVES Identify improved testing to detect pediatric TB infection. METHODS This was a prospective community-based study assessing use of the tuberculin skin test and IFN-γ release assays among children (n = 1,343; 6 mo to <15 yr) in TB-HIV high… CONTINUE READING