Optimizing structural modeling for a specific protein scaffold: knottins or inhibitor cystine knots

Abstract

Knottins are small, diverse and stable proteins with important drug design potential. They can be classified in 30 families which cover a wide range of sequences (1621 sequenced), three-dimensional structures (155 solved) and functions (> 10). Inter knottin similarity lies mainly between 15% and 40% sequence identity and 1.5 to 4.5 Å backbone deviations… (More)
DOI: 10.1186/1471-2105-11-535

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