Optimizing retroviral gene expression for effective therapies.

@article{Antoniou2013OptimizingRG,
  title={Optimizing retroviral gene expression for effective therapies.},
  author={Michael N Antoniou and Kristian Alsbjerg Skipper and Omer Anakok},
  journal={Human gene therapy},
  year={2013},
  volume={24 4},
  pages={
          363-74
        }
}
With their ability to integrate their genetic material into the target cell genome, retroviral vectors (RV) of both the gamma-retroviral (γ-RV) and lentiviral vector (LV) classes currently remain the most efficient and thus the system of choice for achieving transgene retention and therefore potentially long-term expression and therapeutic benefit. However, γ-RV and LV integration comes at a cost in that transcription units will be present within a native chromatin environment and thus be… CONTINUE READING
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