Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.

@article{Cuvelier2009OptimizingOO,
  title={Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.},
  author={Geoff D. E. Cuvelier and Kirk R Schultz and Jeff D Davis and Aaron F. Hirschfeld and Anne K. Junker and Rusung Tan and Stuart E Turvey},
  journal={Clinical immunology},
  year={2009},
  volume={131 2},
  pages={179-88}
}
This FOCIS Centers of Excellence Short Analytical Review is based on the clinical vignette of two boys from the same family with very different outcomes following hematopoietic stem cell transplantation (HSCT) for X-linked severe combined immunodeficiency (SCID). We review the kinetics of immune reconstitution following HSCT in SCID and emphasize the latest information regarding optimizing transplant outcomes for this disorder. The cases illustrate the difficulties and controversies surrounding… CONTINUE READING
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