Optimizing outcomes for patients with advanced disease in chronic myelogenous leukemia.

Abstract

The treatment of chronic myelogenous leukemia (CML) has been revolutionized by the development of the small-molecule tyrosine kinase inhibitor imatinib. The primary target for this drug is the oncogenic BCR-ABL kinase. Five-year survival rates for patients in chronic phase CML is now greater than 80%. Patients who have advanced beyond the chronic phase to… (More)
DOI: 10.1053/j.seminoncol.2007.12.002

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