Optimizing normal tissue sparing in ion therapy using calculated isoeffective dose for ion selection.

@article{Remmes2012OptimizingNT,
  title={Optimizing normal tissue sparing in ion therapy using calculated isoeffective dose for ion selection.},
  author={Nicholas B. Remmes and Michael G. Herman and Jon J. Kruse},
  journal={International journal of radiation oncology, biology, physics},
  year={2012},
  volume={83 2},
  pages={756-62}
}
PURPOSE To investigate how the selection of ion type affects the calculated isoeffective dose to the surrounding normal tissue as a function of both normal tissue and target tissue α/β ratios. METHODS AND MATERIALS A microdosimetric biologic dose model was incorporated into a Geant4 simulation of parallel opposed beams of protons, helium, lithium, beryllium, carbon, and neon ions. The beams were constructed to give a homogeneous isoeffective dose to a volume in the center of a water phantom… CONTINUE READING

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