Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET study.

@article{Bressan2003OptimizingLS,
  title={Optimizing limbic selective D2/D3 receptor occupancy by risperidone: a [123I]-epidepride SPET study.},
  author={Rodrigo Affonseca Bressan and Kjell Erlandsson and Hugh M. Jones and Rachel S. Mulligan and Peter Joseph Ell and Lyn S. Pilowsky},
  journal={Journal of clinical psychopharmacology},
  year={2003},
  volume={23 1},
  pages={5-14}
}
Selective action at limbic cortical dopamine D2-like receptors is a putative mechanism of atypical antipsychotic efficacy with few extrapyramidal side effects. Although risperidone is an atypical antipsychotic with high affinity for D2 receptors, low-dose risperidone treatment is effective without inducing extrapyramidal symptoms. The objective was to test the hypothesis that treatment with low-dose risperidone results in 'limbic selective' D2/D3 receptor blockade in vivo. Dynamic single photon… CONTINUE READING
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