Optimizing drug development of anti-cancer drugs in children using modelling and simulation.


Modelling and simulation (M&S)-based approaches have been proposed to support paediatric drug development in order to design and analyze clinical studies efficiently. Development of anti-cancer drugs in the paediatric population is particularly challenging due to ethical and practical constraints. We aimed to review the application of M&S in the development… (More)
DOI: 10.1111/bcp.12062


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