Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers.

@article{Grigg1995OptimizingDA,
  title={Optimizing dose and scheduling of filgrastim (granulocyte colony-stimulating factor) for mobilization and collection of peripheral blood progenitor cells in normal volunteers.},
  author={Andrew Grigg and Andrew W Roberts and Heike Raunow and Scott Houghton and Judith E. Layton and Andrew W. Boyd and Katherine M McGrath and Deeb Maher},
  journal={Blood},
  year={1995},
  volume={86 12},
  pages={4437-45}
}
To define an optimal regimen for mobilizing and collecting peripheral blood progenitor cells (PBPC) for use in allogeneic transplantation, we evaluated the kinetics of mobilization by filgrastim (recombinant met-human granulocyte colony-stimulating factor [r-metHuG-CSF]) in normal volunteers. Filgrastim was injected subcutaneously for up to 10 days at a dose of 3 (n = 10), 5 (n = 5), or 10 micrograms/kg/d (n = 15). A subset of volunteers from each dose cohort underwent a 7L leukapheresis on… CONTINUE READING
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