Optimizing continuous-combined hormone replacement therapy for postmenopausal women: a comparison of six different treatment regimens.

@article{Heikkinen2000OptimizingCH,
  title={Optimizing continuous-combined hormone replacement therapy for postmenopausal women: a comparison of six different treatment regimens.},
  author={Jorma E Heikkinen and Raija Vaheri and S M Ahom{\"a}ki and Petri Kainulainen and Arttu Viitanen and Ulla Timonen},
  journal={American journal of obstetrics and gynecology},
  year={2000},
  volume={182 3},
  pages={560-7}
}
OBJECTIVE We sought to determine the optimum estradiol valerate-medroxyprogesterone acetate regimens for efficacy and safety. STUDY DESIGN We performed a 24-month, randomized, double-blind phase II study. Four hundred nineteen women who were postmenopausal for at least 3 years were placed in six parallel treatment groups and received 1 or 2 mg estradiol valerate with either 2.5 or 5 mg medroxyprogesterone acetate. In two groups the dose of estradiol valerate was increased from 1 to 2 mg… CONTINUE READING

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