Optimizing cancer treatments to induce an acute immune response: radiation Abscopal effects, PAMPs, and DAMPs.

Abstract

Clinical results indicate improved survival in poorly differentiated prostate cancer patients following a treatment schedule that maximizes hormone therapy prior to radiation. This may be because of a systemic immune response, called an abscopal effect. A literature review showed an association between acute infection and abscopal cancer remission. This led to the theory that, in the presence of endogenous cancer-specific antigens exposed by cancer necrosis, an innate immune response can adapt to respond to those antigens via a cross-talk mechanism. This theory was validated in an animal model. An acute innate immune T-cell response was stimulated using cluster vaccination with Poly(I:C). In the presence of exogenous cancer-specific antigens, this immune response became adaptive, creating an abscopal effect that resulted in cancer resolution. These concepts may be of clinical value, improving outcomes by inducing systemic abscopal effects.

DOI: 10.1158/1078-0432.CCR-12-1175
01020201520162017
Citations per Year

Citation Velocity: 8

Averaging 8 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Ludgate2012OptimizingCT, title={Optimizing cancer treatments to induce an acute immune response: radiation Abscopal effects, PAMPs, and DAMPs.}, author={Charles M. Ludgate}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2012}, volume={18 17}, pages={4522-5} }