Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificity.

@article{Aagaard2006OptimizingAC,
  title={Optimizing antigen cocktails for detection of Mycobacterium bovis in herds with different prevalences of bovine tuberculosis: ESAT6-CFP10 mixture shows optimal sensitivity and specificity.},
  author={Claus Aagaard and Marc Govaerts and Virginia Meikle and Antonio Vallecillo and Jos{\'e} A. Guti{\'e}rrez-Pabello and Francisco Su{\'a}rez-G{\"u}emes and James B. McNair and Angel Cataldi and C. Helbert Eduardo Espitia and Peter Hvilsh\oj Andersen and John M. Pollock},
  journal={Journal of clinical microbiology},
  year={2006},
  volume={44 12},
  pages={4326-35}
}
Bovine tuberculosis is a major problem in many countries; hence, new and better diagnostic tools are urgently needed. In this work, we have tested ESAT6, CFP10, PE13, PE5, MPB70, TB10.4, and TB27.4 for their potentials as diagnostic markers in field animals from Northern Ireland, Mexico, and Argentina, regions with low, medium, and high prevalences of bovine tuberculosis, respectively. At all three sites, ESAT6 and CFP10 were superior diagnostic antigens, while their combination performed even… CONTINUE READING
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An update on bovine tuberculosis programmes in Latin American and Caribbean countries

  • I. N. de Kantor, V. Ritacco
  • Vet. Microbiol
  • 2006

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