Optimizing Recellularization of Whole Decellularized Heart Extracellular Matrix

@inproceedings{Robertson2014OptimizingRO,
  title={Optimizing Recellularization of Whole Decellularized Heart Extracellular Matrix},
  author={Matthew J. Robertson and Jessica L. Dries-Devlin and Stefan M. Kren and Jana S. Burchfield and Doris A Taylor},
  booktitle={PloS one},
  year={2014}
}
RATIONALE Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. However, after transplantation, these acellular vascular conduits clot, even with anti-coagulation. Here, our objective was to create a less thrombogenic scaffold and improve recellularized-left ventricular contractility by re-lining… CONTINUE READING

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