Optimizing Melphalan Pharmacokinetics in Regional Melanoma Therapy: Does Correcting for Ideal Body Weight Alter Regional Response or Toxicity?

@article{McMahon2008OptimizingMP,
  title={Optimizing Melphalan Pharmacokinetics in Regional Melanoma Therapy: Does Correcting for Ideal Body Weight Alter Regional Response or Toxicity?},
  author={Nicole McMahon and Tyen Yee Cheng and Georgia M Beasley and Ivan Spasojevi{\'c} and William P. Petros and Christina K. Augustine and Peter F Zipfel and James C. Padussis and Gretchen M. Sanders and Douglas S. Tyler},
  journal={Annals of Surgical Oncology},
  year={2008},
  volume={16},
  pages={953-961}
}
BackgroundThis study aims to determine what effect correcting melphalan dosing for ideal body weight (IBW) has on toxicity and response in isolated limb infusion (ILI) in patients with advanced extremity melanoma.MethodsThis was an open observational study examining whether correcting the melphalan dose for IBW will influence response and toxicity in patients undergoing ILI for advanced extremity melanoma in 41 patients undergoing 42 procedures (13 without correction for IBW; and 29 with… CONTINUE READING
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