Optimizing Escherichia coli as a protein expression platform to produce Mycobacterium tuberculosis immunogenic proteins

@inproceedings{Piubelli2013OptimizingEC,
  title={Optimizing Escherichia coli as a protein expression platform to produce Mycobacterium tuberculosis immunogenic proteins},
  author={Luciano Piubelli and Manuela Campa and Caterina Temporini and Elisa Binda and Francesca Mangione and M Amicosante and Marco Terreni and Flavia Marinelli and Loredano Pollegioni},
  booktitle={Microbial cell factories},
  year={2013}
}
BACKGROUND A number of valuable candidates as tuberculosis vaccine have been reported, some of which have already entered clinical trials. The new vaccines, especially subunit vaccines, need multiple administrations in order to maintain adequate life-long immune memory: this demands for high production levels and degree of purity. RESULTS In this study, TB10.4, Ag85B and a TB10.4-Ag85B chimeric protein (here-after referred as full)--immunodominant antigens of Mycobacterium tuberculosis--were… CONTINUE READING
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