Optimizing Cancer Radiotherapy with 2-Deoxy-D-Glucose

  title={Optimizing Cancer Radiotherapy with 2-Deoxy-D-Glucose},
  author={Dinesh Kumar Singh and Ajit Kumar Banerji and Bilikere Srinivasarao Dwarakanath and Rajendra Prasad Tripathi and Jaganath P. Gupta and T. Lazar Mathew and Turuga Ravindranath and Viney Kumar Jain},
  journal={Strahlentherapie und Onkologie},
Higher rates of glucose utilization and glycolysis generally correlate with poor prognosis in several types of malignant tumors. Own earlier studies on model systems demonstrated that the nonmetabolizable glucose analog 2-deoxy-D-glucose (2-DG) could enhance the efficacy of radiotherapy in a dose-dependent manner by selectively sensitizing cancer cells while protecting normal cells. Phase I/II clinical trials indicated that the combination of 2-DG, at an oral dose of 200 mg/kg body weight (BW… CONTINUE READING
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