Optimized synthesis of phosphatidylserine


The synthesis of phosphatidyl serine containing saturated fatty acids was thoroughly studied and optimized in order to establish a protocol amenable to large-scale synthesis. The key step was a one-pot multicomponent reaction involving an O-benzyl phosphorodiamidite, protected serine and diacylglycerol, followed by in situ oxidation of the resulting phosphite. In order to replace expensive and poorly stable tetrazole, a screening of substitutes was carried out and imidazolium chloride was selected as the best suited one.

DOI: 10.1007/s00726-009-0447-0

Cite this paper

@article{Guanti2009OptimizedSO, title={Optimized synthesis of phosphatidylserine}, author={Giuseppe Guanti and Luca Banfi and Andrea Basso and L. Bondanza and Giorgio Guglieri and Kristina Powles and Renta Riva}, journal={Amino Acids}, year={2009}, volume={39}, pages={367-373} }