Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar-protein interaction studies.

Abstract

An improved procedure for solid phase coupling of Boc-aminooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glycoprobe precursors in glycomic studies. 

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Cite this paper

@article{JimnezCastells2007OptimizedSO, title={Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar-protein interaction studies.}, author={Carmen Jim{\'e}nez-Castells and Beatriz Garcia de la Torre and Ricardo Guti{\'e}rrez Gallego and David Andreu}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 18}, pages={5155-8} }