Optimized strategies for sequence-tagged-site selection in genome mapping.

  title={Optimized strategies for sequence-tagged-site selection in genome mapping.},
  author={Michael J. Palazzolo and Stanley A. Sawyer and Christopher H Martin and David A. Smoller and Daniel L. Hartl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 18},
The physical mapping of complex genomes is based on the construction of a genomic library and the determination of the overlaps between the inserts of the mapping clones in order to generate an ordered, cloned representation of nearly all the sequences present in the target genome. Evaluation of the relative efficiency of experimental procedures used to accomplish this goal must minimally include a comparison of the fraction of the genome covered by the ordered arrays (or "contigs"), the… CONTINUE READING

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Genomics , in press . 8038 Genetics : Palazzolo et al .

  • R. Arratia, E. S. Lander, S. Tavard
  • 1991

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