Optimized sample preparation for MALDI mass spectrometry analysis of protected synthetic peptides

  title={Optimized sample preparation for MALDI mass spectrometry analysis of protected synthetic peptides},
  author={Audrey M Schaiberger and J. Moss},
  journal={Journal of the American Society for Mass Spectrometry},
The recent development and commercialization of Fuzeon (enfuvirtide) demonstrated that a convergent strategy comprised of both solid- and solution-phase synthetic methodologies presents a viable route for peptide manufacturing on a multi-ton scale. In this strategy, the target sequence is prepared by stepwise solid-phase synthesis of protected peptide fragments, which are then coupled together in the solution-phase to give the full-length sequence. These synthetic methodologies pose a unique… Expand
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The measurement and analysis of molecular weight and molecular weight distribution remain matters of fundamental importance for the characterization and physical properties of polymers. GelExpand
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  • J. Stults
  • Chemistry, Medicine
  • Current opinion in structural biology
  • 1995
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