Optimized parameters for microencapsulation of pancreatic islet cells: an in vitro study clueing on islet graft immunoprotection in type 1 diabetes mellitus.

@article{Basta2004OptimizedPF,
  title={Optimized parameters for microencapsulation of pancreatic islet cells: an in vitro study clueing on islet graft immunoprotection in type 1 diabetes mellitus.},
  author={Giuseppe Basta and Paola Sarchielli and Giovanni De Luca and Leda Racanicchi and Claudio Nastruzzi and Lucia Guido and Francesca Mancuso and Giacomo Macchiarulo and Giovanna Calabrese and Paolo Brunetti and Riccardo Calafiore},
  journal={Transplant immunology},
  year={2004},
  volume={13 4},
  pages={289-96}
}
Alginate (AG)-based microcapsules may provide a selective permeable and biocompatible physical barrier to prevent islet graft (TX)-directed immune destruction. However, extent of the achieved immunoprotection will continue to be variable and unpredictable until the role of the individual mechanisms involved with TX-related inflammatory cell and immune reactivity are clarified. Macrophages (M) are believed to play a pivotal role in controlling the host/TX interaction and its consequences. We… CONTINUE READING
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