Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry.

@article{Sato2014OptimizedMF,
  title={Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry.},
  author={Yuichiro Sato and Masanori Nagata and Kazuhiro Tetsuka and Kouichi Tamura and Aiji Miyashita and Akio Kawamura and Takashi Usui},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 5},
  pages={
          885-9
        }
}
The aim of this study was to optimize methods for quantifying 13 uridine 5'-diphosphate-glucuronosyltransferase (UGT) isoforms (UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10, 2B4, 2B7, 2B10, 2B15, and 2B17) in human liver, intestinal, and kidney microsomes, and in recombinant human UGT-expressing insect cell membranes (rhUGTs) by targeted peptide-based quantification using liquid chromatography-tandem mass spectrometry. Production of targeted peptides was compared by combining three denaturing… CONTINUE READING
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