Optimized immunohistochemistry in combination with image analysis: a reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer.

@article{Lang2013OptimizedII,
  title={Optimized immunohistochemistry in combination with image analysis: a reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer.},
  author={Dagmar Silvia Lang and Uwe Heilenk{\"o}tter and W. Schumm and Olav Max Behrens and Richard T. Simon and Ekkehard Vollmer and Thorsten Goldmann},
  journal={Breast},
  year={2013},
  volume={22 5},
  pages={736-43}
}
The determination of the invasion markers urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) has further improved the possibilities for individualized therapy of breast cancer. To date, quantitative measurement by ELISA, that needs large amounts of fresh, frozen material, is the only standardized procedure for diagnostic purposes. Therefore, the aim of this study was the establishment of a reliable alternative method based on immunohistochemistry (IHC) and… CONTINUE READING
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