Optimized conversion of L-lysine to L-pipecolic acid using recombinant lysine cyclodeaminase from Streptomyces pristinaespiralis

@article{Byun2015OptimizedCO,
  title={Optimized conversion of L-lysine to L-pipecolic acid using recombinant lysine cyclodeaminase from Streptomyces pristinaespiralis},
  author={Sung Min Byun and Seong Wook Jeong and Dae Haeng Cho and Yong Hwan Kim},
  journal={Biotechnology and Bioprocess Engineering},
  year={2015},
  volume={20},
  pages={73-78}
}
Lysine cyclodeaminase (LCD; EC: 4.3.1.28) is a β-nicotinamide adenine dinucleotide-dependent enzyme that catalyzes the β-deamination of L-lysine to produce L-pipecolate. L-pipecolate, also known as L-homoproline, is an immunosuppressant and can be incorporated into multiple secondary metabolite products. Recombinant lysine cyclodeaminase from Streptomyces pristinaespiralis (spLCD) has been successfully expressed in E. coli. Among various substrates with different carbon lengths and enantiomeric… CONTINUE READING

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