Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV.

@article{Taub2002OptimizedCF,
  title={Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV.},
  author={Mitchell E. Taub and Lisbeth Kristensen and Sven Frokjaer},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2002},
  volume={15 4},
  pages={331-40}
}
The solubility enhancing effects of various excipients, including their compatibility with in vitro permeability (P(app)) systems, was investigated using drugs representative of Biopharmaceutics Classification System (BCS) classes I-IV. Turbidimetric solubility determination using nephelometry and transport experiments using MDCK Strain I cell monolayers were employed. The highest usable concentration of each excipient [dimethyl sulfoxide (DMSO), ethanol, hydroxypropyl-beta-cyclodextrin (HPCD… CONTINUE READING
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