Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression.

@article{Fujinaga2002OptimizedCB,
  title={Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression.},
  author={Koh Fujinaga and Dan Irwin and Matthias Geyer and Boris Matija Peterlin},
  journal={Journal of virology},
  year={2002},
  volume={76 21},
  pages={10873-81}
}
The human cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the transactivator Tat and the transactivation response (TAR) RNA stem loop from human immunodeficiency virus type 1 (HIV). This complex activates the elongation of viral transcription. To create effective inhibitors of Tat and thus HIV replication, we constructed mutant hCycT1 proteins that are defective in binding its kinase partner, Cdk9, or TAR. Although these mutant hCycT1 proteins did… CONTINUE READING
13 Citations
51 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors

  • D. Wang, C. de la Fuente, +9 authors F. Kashanchi
  • J. Virol
  • 2001

Interaction between cyclin T 1 and SCFSKP 2 targets CDK 9 for ubiquitination and degradation by the proteasome

  • R. B. Gaynor
  • Mol . Cell . Biol .
  • 2001

Similar Papers

Loading similar papers…