Optimized cannula design and placement for convection-enhanced delivery in rat striatum.

@article{Yin2010OptimizedCD,
  title={Optimized cannula design and placement for convection-enhanced delivery in rat striatum.},
  author={Dali Yin and John R. Forsayeth and Krystof S. Bankiewicz},
  journal={Journal of neuroscience methods},
  year={2010},
  volume={187 1},
  pages={46-51}
}
The stereotactic delivery of therapeutic agents into brain has been problematic because of reflux and leakage of the delivered agent. Good distribution of infusates by convection-enhanced delivery (CED) depends very much on cannula design, precise cannula placement and infusion rates. We have recently published cannula targeting data for the non-human primate (NHP) putamen in which we defined infusion parameters referred to as "red", "blue", and "green" zones for cannula placements that result… CONTINUE READING