Optimized and Validated RP-UPLC Method for the Determination of Losartan Potassium and Chlorthalidone in Pharmaceutical Formulations.

@article{Sirisha2015OptimizedAV,
  title={Optimized and Validated RP-UPLC Method for the Determination of Losartan Potassium and Chlorthalidone in Pharmaceutical Formulations.},
  author={Tadiboyina Sirisha and Bannimath Gurupadayya and Sridhar Siddiraju},
  journal={Advanced pharmaceutical bulletin},
  year={2015},
  volume={5 1},
  pages={133-6}
}
PURPOSE A validated ultra performance liquid chromatography (UPLC) method has been developed and validated for the simultaneous determination of losartan potassium and chlorthalidone in pharmaceutical preparations. METHODS Waters-Acquity UPLC system equipped with Auto Sampler, PDA detector and operated with Empower-2 software was used for the present study. Detection was done at wavelength of 230 nm, HSS C18, 100 mm x 2.1x 1.8 μm column with a reverse phase elution and mobile phase composed… CONTINUE READING